Tucson Police say they have received information that a group of five people, including two males and three females, may have information about the disappearance of 6-year old Isabel Celis.

Detectives tell KNST News, they believe the group was walking eastbound along the northern side of Saint Joseph's Catholic Church, located at 215 South Craycroft, at approximately 1:00 a.m. to 1:30 a.m. on Saturday, April 21, 2012, the day Celis was reported missing.

Police say the group may have been walking in the direction of or directly to East Cooper Street.

According to detectives, the group may have been leaving the area of the Cactus Moon nightclub or Risky Business restaurant and bar, located in the area of east Broadway Boulevard and South Craycroft Road.

Police are now urging members of the group to call 911 as soon as possible.

So far, police have received more than 300 leads in the case, and they remain hopeful of finding her.

At a news conference Friday morning, police say they're encouraging people to call in with any information or tips they may have. They are interested in hearing from people who were at freedom park last Friday night, especially if they have any video from that area. Isabel was there watching a baseball game with her family.

She disappeared from her bedroom that night or early the next morning.

Tucson Police say they still remain hopeful of finding her.     

On Thursday, members of the Pima County Search and Rescue Team used a pontoon equipped with sonar and underwater cameras, to search the lake at Lakeside park, near South Pantano and East Golf Links. Detectives say they were working on a tip, and looking for clues into her disappearance, but they didn't find anything.

Police say they have also scoured three other lakes and parks, including Kennedy, Christopher Columbus, and Reid Park.

Also Thursday, a potential ear-witness came forward in the case. Alicia Stardevent, a neighbor who lives east of the Celis home on East 12th Street, said she heard the family's dogs "going crazy", as well as male voices at approximately 6:30 a.m. - 90-minutes before Celis was reported missing by her father.

At a Friday morning news conference, police say they're encouraging people to call in with any information or tips they may have. They are interested in hearing from people who were at Freedom Park last Friday night, especially if they have any video from that area. Isabel was there watching a baseball game with her family.

Anyone with video or tips about Isabel's case can call 88-Crime. A reward in the case has grown to $50,000, as of Friday evening.